Our paper on SRSF6 as a key factor in the alternative splicing response to hypoxia is out in Nucleic Acids Research. We could show that the reduction of SRSF6 levels under acute hypoxia is necessay to decrease the inclusion of numerous cassette exons and to trigger the dispersal of nuclear speckles. Downregulation of SRSF6 is achieved via the inclusion of a poison cassette exon promoted by SRSF4. Abolishment of SRSF6 reduction resulted in increased proliferation, genomic instability and suppresion of the stress response.

de Oliveira Freitas Machado et al 2023